This route connects two major metropolitan areas of the Pacific Northwest, Vancouver, British Columbia, and Seattle, Washington. The journey typically involves traversing the international border between Canada and the United States. A common method involves utilizing Interstate 5, a major north-south highway on the West Coast.
The connection facilitates significant economic and cultural exchange between the two cities and their respective regions. It enables trade, tourism, and the movement of people for work and leisure. This accessibility fosters a strong sense of interconnectedness within the Cascadia bioregion. Historically, the route has evolved alongside improvements in transportation infrastructure, reflecting the growing relationship between these Pacific Northwest hubs.